West Macedonia is one of the thirteen peripheries of Greece, consisting of the western part of the region of Macedonia. It is divided into the peripheral units of Florina, Grevena, Kastoria, and Kozani.

The periphery of West Macedonia is situated in north-western Greece, bordering with the peripheries of Central Macedonia (east), Thessaly (south), Epirus (west), and bounded to the north at the international borders of Greece with the Republic of Macedonia (Bitola region) and Albania (Korçë region).

Although it covers a total surface of 9,451 km2  (7,2% of country’s total), it has a total population of 302,892 inhabitants (2.9% of the country’s total), thus it is a low-density populated Region . This is mainly due to the mountainous nature of the Region, as 82% of the total surface are mountainous and semi-mountainous areas. This is also reflected in the population distribution, as the major part of the population  lives in rural areas. Capital of the periphery is Kozani with 47,451 inhabitants. Other main towns are Ptolemaida , Grevena , Florina and Kastoria .

The West Macedonia region was established in the 1987 administrative reform, comprising the prefectures of Kastoria, Grevena, Kozani and Florina.With the 2010 Kallikratis Programme (Act 3852/2010), its powers and authority were redefined and extended. The region is based at Kozani and is divided into four regional units (the pre-Kallikratis prefectures), which are further subdivided into 12 municipalities (down from 61 pre-Kalikratis local administrative units). Along with Epirus it is supervised by the Decentralized Administration of Epirus and West Macedonia based at Ioannina.

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