East Macedonia and Thrace is one of the thirteen peripheries of Greece. It consists of the northeastern parts of the country, comprising the eastern part of the region of Macedonia along with the region of Thrace, and the islands of Thasos and Samothrace.

East Macedonia and Thrace was established in the 1987 administrative reform. With the 2010 Kallikratis plan, its powers and authority were redefined and extended. Along with Central Macedonia, it is supervised by the Decentralized Administration of Macedonia and Thrace based at Thessaloniki.

The region is based at Komotini. It is divided into the Macedonian regional units of Drama, Kavala and Thasos and the Thracian regional units of Xanthi, Rhodope and Evros.

Before the Kallikratis reform, the regional units (except Thasos, which was part of Kavala) were administered as separate prefectures.Since 1994, they were grouped into the Drama-Kavala-Xanthi and Rhodope-Evros super-prefectures.

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